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Using one-molecule optical and AFM imaging and pressure-spectroscopy strategies, we seek out to unravel the mechanistic aspects of the composition and dynamics of chromosomes. Our exploration pursuits include:

It had been only inside the nineties nevertheless, when nanotechnology experienced advanced to your amount the place single molecules may be manipulated, that the very first experimental equipment started to seem.

Back in 1991, Sumio Iijima from the NEC Corporation had reported the synthesis of carbon nanotubes. Band structure calculations advised that these nanotubes could exhibit metallic band conduction. This could be a substantial benefit above the conducting polymers we had explored, which have been, in truth, disordered semiconductors featuring basically variable-variety hopping conductivity.

2007, initial authentic-time detection of strand exchange in homologous recombination by RecA; discovery of a very low persistence duration of ends of microtubules; and solved the system of biosensing with carbon nanotubes

2015, discovery that condensin is usually a remarkably versatile protein structure; and initially detection of DNA knots employing nanopores

Instance (3) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is proven in grey, the rim with the pore is highlighted in red, and a 3D rendering of your movement on the DNA rod is displayed.

We form germs into forms that deviate from their natural phenotype. Specifically, I'll exhibit our capacity to shape live E. coli microbes into novel styles for example rectangles, squares, triangles and circles.

Atomic power microscopy demonstrates that vaccinia topoisomerase IB generates filaments on DNA inside of a cooperative style

Being familiar with fundamental procedures regulating the spatial and dynamic organisation of the DNA in live cells.

‘The fantastically subtle way in which features in mother nature functionality under no circumstances ceases to amaze me. If we fix the puzzle of how existence came into remaining, I hope that my amazement with the complexity of development may have increased and with it my awe with the greatness on the Creator.’

Case in point (four) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is shown in gray, the rim with the pore is highlighted in purple, as well as a 3D rendering from the movement of your DNA rod is shown.

2001, discovery of one-electron transistors at home temperature dependant on nanotubes; realization of first logic circuits with carbon nanotube gadgets; and discovery from the molecular construction of DNA fix enzymes with AFM

Permit’s initially glimpse back in the meanwhile any time you made a decision to change your aim from superconductivity and ceesdekker nanotubes to biology at the conclusion of the nineteen nineties.

Supercoiling-dependent DNA binding: quantitative modeling and applications to bulk and one-molecule experiments